Ответ:

+ they have got a bike  

— they haven`t got a bike  

?  Have they got a bike ?

+She has a big cake  

—  She doesn`t have a big cake  

?  Does she have a big cake  ?

+My sister has got a dog

— My sister hasn`t got a dog

?  Has my sister got a dog?

+Children have toys

?  Do children have toys?

—  Children don`t have toys